Engine

The MC12 sports a 232 kilogram (511 lb), six-litre (5,998 cc/366 cu in) Enzo Ferrari-derived V12 engine, mounted at 65°. Each cylinder has four valves, lubricated via a dry sump system, and a compression ratio of 11.2:1. These combine to provide a maximum torque of 652 newton metres (481 lbf•ft) at 5500 rpm and a maximum power of 465 kilowatts (632 PS/621 bhp) at 7500 rpm. The redline rpm is indicated at 7500—despite being safe up to 7700—whereas the Enzo has redline at 8200 rpm.

Chassis

The MC12’s chassis is a monocoque made of carbon and nomex, with an aluminium sub-chassis at the front and rear. It has a roll bar to provide additional strength, comfort and safety. Double wishbone suspension with push-rod-operated coil springs provide stability and dampers smooth the ride for the passengers. The front of the car can be raised for speed bumps and hills by pressing a button that extends the front suspension. There are two modes for the chassis' tuning which can also be changed with a button in the cabin: Sport, the standard setting, and Race, which features less of the Bosch ASR (Anti-Slip Regulation) traction control, faster shifts and stiffer suspension.
 
Wheels

The MC12 has 48 centimetre (19 in) wheels with a width of 23 centimetres (9 in) at the front and 33 centimetres (13 in) at the rear. The tyres are Pirelli P Zero Corsas with codes of 245/35 ZR 19 for the front tyres and 345/35 ZR 19 for the rear. The brakes are Brembo disc brakes with a Bosch anti-lock braking system (ABS). The front brakes have a diameter of 380 millimetres (15 in) with six-piston calipers and the rear brakes have a diameter of 335 millimetres (13.2 in) with four-piston calipers. The centre-lock wheel nuts that hold the wheels to the chassis are colour coded: red on the left of the car, blue on the right.
 
Reception

The car has generally received positive reviews, but its critics say it is hard to drive, overpriced and too large. Other criticisms include the lack of a boot, rear window, spare tyre and radio, and the way the car's engine was limited or "drugged". Current driver for Vitaphone Racing Team Andrea Bertolini, the chief test driver throughout the development, said the car "reacts well and is very reliable in its reactions".

The Top Gear television series acquired an MC12, and test driver The Stig achieved a lap time of 1:18.9 around the Top Gear track—0.1 seconds faster than his lap in the Enzo Ferrari. Host Jeremy Clarkson also drove it, comparing it to the Maserati Biturbo, a car he disliked. Clarkson criticised the car heavily, pointing out its lack of a rear window and its size. He also commented that it is "difficult" due to its size, and "one of the twitchiest cars" he has ever driven, meaning a small action by the driver results in an exaggerated reaction from the car. Regarding the design of a racing car and modification to road standards he said, "Is it a racer? Is it a GT car? Is it a de-tuned Enzo in a fat suit? You can't really tell." Despite his criticisms he did compliment the smooth ride:

Motor Trend Magazine reviewer Frank Markus had a more positive opinion. Despite initial skepticism he said, "It turns out that the Enzo makes a more comfortable and attractive road car when made over as a butch Maserati racer in street couture". Markus complimented the stability of braking and the handling ability of the MC12, especially the drifting allowed by the traction control when cornering, commenting that "There's none of the knife-edged limit handling we criticised in the more extreme Enzo. It's even more forgiving at the limit than an Acura NSX.
 
When Automobile Magazine tested an MC12, reviewer Preston Lerner called it "user-friendly", praising the responsiveness and simplicity of driving. Lerner approved of Frank Stephenson's work with the styling of both the car's exterior and interior, calling the trim "Speed-Racer-ish" but "without looking as though it belongs in a Nitrous-ized Civic". He also complimented the ASR's level of intervention, commenting that it "lets the fun factor get reasonably high before kicking in".